NeuroEng@Usach
NeuroEng@Usach
Research
News
People
Events
Publications
Projects
Contact
Light
Dark
Automatic
Recent & Upcoming Events
2026
Interpretable machine learning of micro-ERG reveals muted retinal gain tracking in 5xFAD mice
Presented a poster on using interpretable machine learning on micro-ERG signals to discriminate WT from 5xFAD retinas, identifying muted gain tracking as a key biomarker.
Aug 31, 2026 — Sep 3, 2026
Centro de Extensión UC - Alameda
Leo Medina
,
Joel Villalobos
,
Adrian Palacios
,
David B. Grayden
,
Joseph West
Project
Project
XBP1s-Mediated Rescue of Retinal Function in Aging and Alzheimer's Disease Models.
Discussed the therapeutic potential of XBP1s overexpression in preserving retinal function during aging and Alzheimer’s disease pathology in mouse models.
Feb 16, 2026 — Feb 18, 2026
University of New South Wales
Leo Medina
Project
2025
Complexity-based analysis of retinal electrophysiology in neurodegenerative diseases.
A talk presenting complexity-based analysis of retinal electrophysiology (micro-ERG) to discover noninvasive ocular biomarkers for neurodegenerative diseases.
Dec 10, 2025 1:00 PM — 2:00 PM
School of Optometry & Vision Sciences - University of Auckland
Leo Medina
Project
Complexity-based analysis of retinal electrophysiology in neurodegenerative diseases.
Aug 19, 2025 1:00 PM — 2:00 PM
FBE Building - The University of Melbourne
Leo Medina
Project
Novel Tools for Retinal Biomarkers in Neurodegenerative Conditions
Presented recent work on using multiscale entropy (MSE) and complexity-loss theory to detect neurodegenerative conditions via retinal electrophysiology.
May 29, 2025 12:00 PM — 1:00 PM
BME Boardroom - The University of Melbourne
Leo Medina
Project
2024
Protective Mechanisms in Retinal Aging: The Role of XBP1s in Alzheimer's Disease Mouse Models
Presented a study exploring the protective role of transcription factor XBP1s overexpression in retinal aging and neurodegeneration using multiscale entropy.
Oct 9, 2024 8:00 AM — 12:00 PM
McCormick Place
Leo Medina
,
Maximiliano Orellana
,
Bruno Cerda
,
Cristóbal Rojas
,
Max Chacón
,
Claudia Duran-Aniotz
,
Claudio Hetz
,
Daniela Ponce
,
David Neira
,
Francisco Miqueles
,
Joaquín Araya-Arriagada
,
Adrian Palacios
Project
La retina como ventana al cerebro: Aplicación de algoritmos de complejidad para la detección de enfermedades neurodegenerativas
Jul 17, 2024 4:00 PM — 5:00 PM
Hotel Best Western Premier Marina
Leo Medina
Project
La retina como ventana al cerebro: Aplicación de algoritmos de complejidad para la detección de enfermedades neurodegenerativas
Jan 3, 2024 2:30 PM — 3:00 PM
Universidad Autónoma de Chile
Leo Medina
Project
2023
La retina como ventana al cerebro: Aplicación de algoritmos de complejidad para la detección de enfermedades neurodegenerativas
Aug 19, 2023 12:00 PM — 1:00 PM
Hotel Interamericano
Leo Medina
Project
Análisis de complejidad de señales biológicas: Aplicación a la detección de enfermedades neurodegenerativas a través del ojo
Presentación sobre el uso del análisis de entropía multiescala (MSE) en electrorretinogramas (ERG) para la detección temprana de la enfermedad de Alzheimer.
Jun 1, 2023 12:00 PM — 1:00 PM
Centro de Investigación Biomédica y Aplicada, Universidad de Santiago de Chile
Leo Medina
Project
Complexity analyses of biological signals for detection of Alzheimer’s disease through the eye
Discussed using entropy-based complexity metrics like multiscale entropy (MSE) on electroretinogram (ERG) signals to detect Alzheimer’s disease.
Feb 17, 2023 11:00 AM — 12:00 PM
Emory University
Leo Medina
Project
Complexity analyses of biological signals: application to neurodegenerative disease detection through the eye
Jan 27, 2023 12:00 PM — 1:00 PM
Duke University
Leo Medina
Project
2022
Slow Inactivation of Fast Sodium Channels Mediates Accommodation of Nerve Fiber Activity During Kilohertz-Frequency Spinal Cord Stimulation
Presented research combining computational modeling and in vivo measurements to clarify how slow inactivation of sodium channels mediates accommodation during KHF SCS.
Dec 5, 2022 2:15 PM — 2:45 PM
Hotel Enjoy
Leo Medina
,
Nathan Titus
,
Warren M. Grill
An automatic method for detection of evoked events in the brain during spinal cord stimulation
Presented an automatic method for detecting evoked potentials in the brain during spinal cord stimulation for Parkinson’s disease.
Nov 10, 2022 2:45 PM — 3:00 PM
Universidad Técnica Federico Santa María
Nicolás Vásquez
,
Mario Cáceres
,
Rómulo Fuentes
,
Leo Medina
Multiscale Entropy Analysis of Biomedical Signals
Organized a special session reviewing multiscale entropy (MSE) and complexity tools for biological signal analysis and disease diagnosis.
Oct 25, 2022 2:00 PM — 3:00 PM
Online Event
Leo Medina
,
Cristóbal Rojas
,
Osvaldo Rosso
2021
Multi-Scale Entropy Analysis of Retinal Signals in an Animal Model of Alzheimer’s Disease
Nov 2, 2021 12:00 AM
Online Event
Sebastián Garay
,
Joaquín Araya-Arriagada
,
Cristóbal Rojas
,
Adrián Palacios
,
Max Chacón
,
Leo Medina
Teoría de la complejidad en sistemas biológicos
Webinar sobre la teoría de la complejidad en sistemas biológicos, presentando el trabajo y las líneas de investigación del laboratorio de Informática Biomédica.
Aug 4, 2021 11:30 AM — 1:00 PM
DIINF - Universidad de Santiago de Chile
Max Chacón
,
José Luis Jara
,
Leo Medina
Video
Neuroingeniería en la Usach
Jul 20, 2021 11:20 AM — 11:50 AM
Universidad de Santiago de Chile
Leo Medina
2020
Medicina Bioeléctrica Computacional
Nov 26, 2020 11:00 AM — 12:00 PM
Pontificia Universidad Javeriana
Leo Medina
Project
Video
Design of a Low Cost Neuromuscular Blockade Monitoring Device
Presented a prototype of a low-cost, open-source neuromuscular blockade monitoring device based on acceleromyography.
Nov 19, 2020 10:00 AM — 10:20 AM
Okinawa, Japan
Leo Medina
,
Manuel Villalobos-Cid
,
Arturo Álvarez
,
Pedro Chaná-Cuevas
Model Quantification of Axon Responses to Kilohertz SCS for the Treatment of Chronic Pain
Oct 30, 2020 11:50 AM — 12:10 PM
Universidad de Santiago de Chile
Leonel E. Medina
,
Warren M. Grill
Project
Invasive brain-machine interfaces
Oct 6, 2020 6:30 PM — 8:30 PM
Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Santiago
Leo Medina
2019
Brain-machine interfaces
In this talk, we will discuss the principles underlying extracellular recording of single neuron activity in the brain, spike sorting …
Oct 3, 2019 4:30 PM — 6:30 PM
Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Santiago
Leonel E. Medina
A DSGC-SAC Network Model of Direction Selectivity in the Mammalian Retina
Jul 2, 2019 2:30 PM — 2:50 PM
Frejus, France
Leo Medina
Project
2017
Quantification of dorsal column fiber responses in a model of kilohertz-frequency spinal cord stimulation
Introduction: Kilohertz-frequency spinal cord stimulation (KHF-SCS) was recently proposed as a paresthesia-free treatment for persons …
Oct 31, 2017 12:00 AM
Baltimore, MD, USA
Leonel E. Medina
,
Nathan Crosby
,
John Janik
,
Warren Grill
Model Quantification of Direction Selectivity in Starburst Amacrine Cells in the Mammalian Retina
Detection of motion direction in the visual system of rodents is observed at processing stages as early as the retinal circuitry. …
Oct 2, 2017 12:00 AM
Castro, Chiloé, Chile
Leonel E. Medina
,
Samy Castro
,
Javier Palma
,
María José Escobar
,
Patricio Orio
Project
Cite
×