Precision functional neuroimaging reveals individually specific auditory responses in infants

Julia Moser, Alyssa K. Labonte, Thomas J. Madison, Lana Hantzsch, Han H. N. Pham, Kimberly B. Weldon, M. Catalina Camacho, Rebecca F. Schwarzlose, Sanju Koirala, Jacob T. Lundquist, Sooyeon Sung, Cristian Morales, Robert J. M. Hermosillo, Steven M. Nelson, Jed T. Elison, Damien A. Fair, Chad M. Sylvester
January 2025
Cite DOI

Abstract

Adaptively responding to salient stimuli in the environment is a fundamental feature of cognitive development in early life, which is enabled by the developing brain. Understanding individual variability in how the brain supports this fundamental process is essential for uncovering neurodevelopmental trajectories and potential neurodevelopmental risks. In the present study, we used a precision functional imaging approach to probe activation in response to salient auditory stimuli and its relation to brain functional networks in individual infants. A minimum of 60 minutes of fMRI BOLD data with an auditory oddball paradigm were collected in ten infants with a mean postmenstrual age of 48 weeks. Results demonstrate the feasibility of conducting a precision functional imaging study to investigate individual specific responses to salient stimuli in infants. While responses to the auditory oddball were consistent across …

Type
Preprint
Publication
bioRxiv
Cristian Morales
Cristian Morales
Principal Investigator

Cristian Morales Carrasco is an electrical engineer with an MSc in Electrical Engineering and a PhD in Biomedical Engineering. His research focuses on functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS).